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J Nat Prod. 2009 Jun;72(6):1155-60. doi: 10.1021/np900164b.

Triterpene glycosides from the underground parts of Caulophyllum thalictroides.

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School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.


A total of 22 triterpene glycosides, including 10 new compounds (1-10), were isolated from the underground parts of Caulophyllum thalictroides. The structures of the new glycosides were determined on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses. All 22 compounds were evaluated for cytotoxicity against HL-60 human leukemia cells. The triterpene monodesmosides based on oleanolic acid (1 and 11-16) showed cytotoxic activity against HL-60 cells with IC(50) values that ranged from 3.4 to 15.9 microg/mL.

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