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Rheumatol Int. 2010 Jan;30(3):305-8. doi: 10.1007/s00296-009-0950-3. Epub 2009 May 16.

Bone mineral density in patients with familial Mediterranean fever.

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1
Department of Physical Medicine, Medical Faculty, Ataturk University, Erzurum, Turkey. kadiryildirim88@hotmail.com

Abstract

This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1-4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.

PMID:
19449009
DOI:
10.1007/s00296-009-0950-3
[Indexed for MEDLINE]
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