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J Neurooncol. 2009 Nov;95(2):285-288. doi: 10.1007/s11060-009-9918-0. Epub 2009 May 16.

Neurolymphomatosis: a rare metastatic complication of diffuse large B-Cell lymphoma.

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Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Institute, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Avenue East, Mailstop: G-4940, P.O. Box 19023, Seattle, WA, 98109-1023, USA.
Department of Radiology, University of Washington, Seattle, WA, USA.


To report the occurrence of neurolymphomatosis in a patient with previously treated systemic diffuse B-cell lymphoma (DLBCL). A case report. University medical center. A 54-year old woman with previously treated DLBCL developed sequential mono-, di- and triparesis 3-months after completion of systemic therapy. MR of lumbar and brachial plexus revealed diffuse involvement of nerve roots and plexus. High-dose methotrexate and involved-field radiotherapy. Neurolymphomatosis, although rare, is increasingly recognized with peripheral and central nervous system MRI. Treatment remains unsatisfactory as treatment with methotrexate-based chemotherapy and irradiation is only partially effective.

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