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Nat Chem Biol. 2009 Jul;5(7):462-4. doi: 10.1038/nchembio.177.

Chromatin-level regulation of biosynthetic gene clusters.

Author information

1
Department of Medical Microbiology and Immunology (formerly Department of Plant Pathology), University of Wisconsin-Madison, Madison, Wisconsin, USA.

Abstract

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B. Modification of the chromatin landscape in fungal secondary metabolite clusters allows for a simple technological means to express silent fungal secondary metabolite gene clusters.

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PMID:
19448638
PMCID:
PMC2891026
DOI:
10.1038/nchembio.177
[Indexed for MEDLINE]
Free PMC Article

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