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Cell Cycle. 2009 Jun 15;8(12):1883-7. Epub 2009 Jun 21.

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

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1
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Blagosklonny@oncotarget.com

Abstract

Here I overview the accompanying three reports on suppression of cellular senescence with inhibitors of mTOR, PI-3K and MEK. How can growth inhibitors suppress senescence? May these aging-suppressants decelerate organismal aging? To answer these questions, we need to reconsider the meaning of aging.

PMID:
19448395
DOI:
10.4161/cc.8.12.8815
[Indexed for MEDLINE]
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