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Nephron. 1991;59(1):148-52.

Homozygous C3 deficiency associated with IgA nephropathy.

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1
Department of Internal Medicine, School of Medicine, Tokai University, Isehara, Japan.

Abstract

A 23-year-old male patient with homozygous C3 deficiency who developed asymptomatic proteinuria and hematuria was reported. Renal biopsy disclosed typical IgA nephropathy with deposition of early- and late-complement components except for C3 deposition. C9 and membrane attack complex were detected in the glomeruli despite the absence of C3. It was suggested that there might be some unknown complement activation mechanism which does not require C3 component.

PMID:
1944729
[Indexed for MEDLINE]
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