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Am J Obstet Gynecol. 2009 Jul;201(1):94.e1-10. doi: 10.1016/j.ajog.2009.02.027. Epub 2009 May 15.

Association of genetic ancestry with preterm delivery and related traits among African American mothers.

Author information

1
Mary Ann and J Milburn Smith Child Health Research Program, Children's Memorial Hospital and Children's Memorial Research Center, Chicago, IL 60614-3394 , USA. htsai@childrensmemorial.org

Abstract

OBJECTIVE:

In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors.

STUDY DESIGN:

We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as "black." Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification.

RESULTS:

The estimated African ancestral proportion was 0.90 +/- 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study.

CONCLUSION:

Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.

PMID:
19446788
PMCID:
PMC2859981
DOI:
10.1016/j.ajog.2009.02.027
[Indexed for MEDLINE]
Free PMC Article

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