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Semin Cell Dev Biol. 2009 Aug;20(6):712-8. doi: 10.1016/j.semcdb.2009.04.001. Epub 2009 Apr 10.

Signals from the edges: the cortical hem and antihem in telencephalic development.

Author information

1
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.

Abstract

The early cortical primordium develops from a sheet of neuroepithelium that is flanked by distinct signaling centers. Of these, the hem and the antihem are positioned as longitudinal stripes, running rostro-caudally along the medial and lateral faces, respectively, of each telencepahlic hemisphere. In this review we examine the similarities and differences in how these two signaling centers arise, their roles in patterning adjacent tissues, and the cells and structures they contribute to. Since both the hem and the antihem have been identified across many vertebrate phyla, they appear to be part of an evolutionary conserved set of mechanisms that play fundamental roles in forebrain development.

PMID:
19446478
PMCID:
PMC2791850
DOI:
10.1016/j.semcdb.2009.04.001
[Indexed for MEDLINE]
Free PMC Article

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