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Clin Chem Lab Med. 2009;47(6):777-82. doi: 10.1515/CCLM.2009.163.

Systemic cytokine response following exercise-induced muscle damage in humans.

Author information

1
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Goudi-Athens, Greece.

Abstract

BACKGROUND:

Muscle adaptation which occurs following eccentric exercise-induced muscle damage has been associated with an acute inflammatory response. The purpose of this study was to investigate serum interleukin-6 (IL-6), osteoprotegerin and receptor activator of nuclear factor kB ligand (OPG/RANKL) concentrations following muscle damage. We measured changes for several days following muscle damage.

METHODS:

Ten healthy young males performed an eccentric exercise protocol using their quadriceps. Blood samples were withdrawn before and at 6 h, 2 days, 5 days and 16 days post-exercise. Functional and clinical measurements were performed before, and on days 1, 2, 5, 8, 12 and 16 post-exercise.

RESULTS:

The exercise protocol resulted in muscle damage, indicated by changes in biochemical markers. An increase in IL-6 and OPG, and a decrease in RANKL concentrations were seen at 6 h and on day 2 post-exercise; the OPG:RANKL ratio was increased at 6 h post-exercise (p < 0.05).

CONCLUSIONS:

Changes in IL-6 and OPG/RANKL system may represent systemic responses in muscle inflammation and repair processes. However, further studies are needed to elucidate a potential systemic and/or local role of the OPG/RANKL system in skeletal muscle repair.

PMID:
19445648
DOI:
10.1515/CCLM.2009.163
[Indexed for MEDLINE]

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