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Nature. 1991 Oct 31;353(6347):822-7.

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor.

Author information

1
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Abstract

The induction of heat-shock transcription factor (HSF) binding to DNA is accomplished by a heat-induced oligomerization. The transition to the induced state is accompanied by a chromosomal redistribution of HSF to the heat-shock puff sites. Over 150 additional chromosomal sites also accumulate HSF, including developmental loci that are repressed during heat shock. These findings suggest an unforeseen role for HSF as a repressor of normal gene activity during heat stress.

PMID:
1944557
DOI:
10.1038/353822a0
[Indexed for MEDLINE]

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