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Zh Vyssh Nerv Deiat Im I P Pavlova. 2009 Mar-Apr;59(2):206-12.

[Involvement of presynaptic 5-HT1A receptors in immunomodulation under conditions of psychoemotional state].

[Article in Russian]

Abstract

The development of the immune reaction after the activation or blockade of presynaptic 5-HT1A receptors, respectively, with a selective agonist or antagonist depends on specific behavioral patterns. Agonist of 5-HT1A receptors 8-OH-DPAT (0.1 mg/kg 15 min prior to immunization) did not change the number of IgM plaque-forming cells in the spleen of aggressive mice at the peak of the immune response (the 4-th day after immunization) but increased their number in submissive animals, in which the baseline immune response was lower than in aggressive animals. Administration of WAY-100635 (0.1 mg/kg 30 min prior to immunization) resulted in a decrease in the immune reaction in aggressive mice and led to its increase in submissive animals. It is suggested that the immunomodulatory effects of drugs affecting the activity of presynaptic 5-HT1A receptors are related to changes in the functional state of these receptors and the interaction between serotonin- and dopaminergic systems.

PMID:
19445389
[Indexed for MEDLINE]

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