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Bull Mem Acad R Med Belg. 2008;163(6):355-64; discussion 364-5.

Regulation of human immunodeficiency virus-1 latency and its reactivation.

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1
Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA.

Abstract

Treatment of human immunodeficiency virus (HIV) infection with highly active antiretroviral therapy (HAART) has become highly effective. However the persistence of a small population of infected cells containing transcriptionally silent but re-activatable HIV proviruses prevents complete elimination of the infection. Here, we review recent progress in our understanding of the molecular mechanisms underlying HIV proviral latency and highlight experimental therapies designed to eliminate the latent population.

PMID:
19445107
[Indexed for MEDLINE]
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