Format

Send to

Choose Destination
J Neurovirol. 2009 May;15(3):275-81. doi: 10.1080/13550280902913271.

Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.

Author information

1
Department of Radiology, Northwestern University, Chicago, Illinois 60611-2927, USA. ann-ragin@northwestern.edu

Abstract

Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.

PMID:
19444696
PMCID:
PMC3469319
DOI:
10.1080/13550280902913271
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center