Format

Send to

Choose Destination
Nat Rev Microbiol. 2009 Jun;7(6):460-6. doi: 10.1038/nrmicro2133.

Drug interactions and the evolution of antibiotic resistance.

Author information

1
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

PMID:
19444248
PMCID:
PMC2855488
DOI:
10.1038/nrmicro2133
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center