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Anticancer Res. 2009 May;29(5):1495-7.

Collision tumor versus multiphenotypic differentiation: a case of carcinoma with features of colonic and lung primary tumors.

Author information

1
Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, MMC 480 Minneapolis, MN 55455, U.S.A.

Abstract

BACKGROUND:

Collision tumors are rare tumors composed of two histologically distinct neoplasms coinciding at the same location. Collision tumors need to be distinguished from tumors originating from a progenitor cell with potential for multiphenotypic differentiation.

CASE REPORT:

A clinically puzzling case of an intricate malignant pulmonary nodule in a patient with previous history of colorectal carcinoma is reported. A brief review of the clinical literature on collision tumor and tumor stem cells is presented.

CONCLUSION:

This case report emphasizes the importance of detailed histopathologic and immunohistochemical analyses, and clinical history in diagnosing a tumor composed of multiple malignant morphologies.

PMID:
19443356
[Indexed for MEDLINE]
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