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J Pediatr Urol. 2009 Aug;5(4):308-14. doi: 10.1016/j.jpurol.2009.04.007. Epub 2009 May 14.

Pediatric renal cell carcinoma.

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1
James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287, USA. jsausville@smail.umaryland.edu

Abstract

Renal cell carcinoma (RCC) comprises about 5% of pediatric renal neoplasms. It has been recognized as a second malignancy in multiple reports. It is generally symptomatic at diagnosis, and most children with RCC present with more locally advanced disease than do adults. Contemporary investigation of pediatric RCC has demonstrated that a large percentage of these tumors bear cytogenetic translocations involving the MiT family of transcription factors. Surgical therapy for these children resembles operative intervention for adult RCC, though debate continues about the precise role of lymph node dissection. There are no adequately powered studies to support conclusions about adjuvant or neoadjuvant chemotherapy for children with RCC. This may be ameliorated by a multi-institutional protocol which is enrolling patients.

PMID:
19443274
DOI:
10.1016/j.jpurol.2009.04.007
[Indexed for MEDLINE]
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