Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2009 Aug;21(4):516-21. doi: 10.1016/j.ceb.2009.04.006. Epub 2009 May 13.

Substrate-specific mediators of ER associated degradation (ERAD).

Author information

1
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. jbrodsky@pitt.edu

Abstract

Approximately one-third of newly synthesized eukaryotic proteins are targeted to the secretory pathway, which is composed of an organellar network that houses the enzymes and maintains the chemical environment required for the maturation of secreted and membrane proteins. Nevertheless, this diverse group of proteins may fail to achieve their native states and are consequently selected for ER associated degradation (ERAD). Over the past few years, significant effort has been made to dissect the components of the core ERAD machinery that is responsible for the destruction of most ERAD substrates. Interestingly, however, some ERAD substrates associate with dedicated chaperone-like proteins that target them for proteolysis or protect them from destruction. Other substrates fold and function normally but can be selected for ERAD by protein adaptors that identify and transmit regulatory cues.

PMID:
19443192
PMCID:
PMC2756615
DOI:
10.1016/j.ceb.2009.04.006
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center