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Anticancer Agents Med Chem. 2009 May;9(4):369-80.

Tripentones: a promising series of potent anti-cancer agents.

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1
CERMN UPRES EA 4258 - FR CNRS 3038 INC3M, UFR des Sciences Pharmaceutiques-Université de Caen Basse-Normandie, Bd Becquerel 14032 Caen Cedex, France.

Abstract

The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anti-cancer agents. These compounds belong to the tripentone family and are based on 9H-pyrrolo[1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

PMID:
19442038
[Indexed for MEDLINE]
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