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Dev Dyn. 2009 Jun;238(6):1526-34. doi: 10.1002/dvdy.21972.

Molecular mechanisms of mechanosensing in muscle development.

Author information

1
Department of Biology, McGill University, Montréal, Québec, Canada. klodiana.jani@elf.mcgill.ca

Abstract

Mechanical forces are crucial to muscle development and function, but the mechanisms by which forces are sensed and transduced remain elusive. Evidence implicates the sarcolemmal lattice of integrin adhesion and the Z-disk components of the contractile machinery in such processes. These mechanosensory devices report changes in force to other cellular compartments by self-remodeling. Here we explore how their structural and functional properties integrate to regulate muscle development and maintenance. Developmental Dynamics 238:1526-1534, 2009.

PMID:
19441055
DOI:
10.1002/dvdy.21972
[Indexed for MEDLINE]
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