Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Rev Allergy Immunol. 2010 Feb;38(1):68-74. doi: 10.1007/s12016-009-8130-5.

Genetic insights into congenital neutropenia.

Author information

1
Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany. klein.christoph@mh-hannover.de

Abstract

Congenital neutropenia syndromes comprise a heterogeneous group of disorders leading to increased susceptibility to bacterial infections. Recent work has elucidated the molecular basis of several congenital neutropenia syndromes such as mutations in ELA2, HAX1, GF11, and WAS. In addition, a number of complex clinical syndromes associating congenital neutropenia have been recognized and elucidated on a genetic level, e.g. p14-deficiency or G6PC3-deficiency. The clinical and genetic findings of various neutropenia syndromes are being discussed.

PMID:
19440858
DOI:
10.1007/s12016-009-8130-5
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center