Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuropsychobiology. 2009;59(3):142-50. doi: 10.1159/000218076. Epub 2009 May 12.

DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study.

Author information

1
HUBIN Project, Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden. erik.jonsson@ki.se

Abstract

BACKGROUND:

Several studies of the dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes and schizophrenia.

METHODS:

In a replication attempt, single-nucleotide polymorphisms of the DTNBP1, NRG1, DAO, DAOA, and GRM3 genes were analyzed in three independent Scandinavian schizophrenia case-control samples.

RESULTS:

One DTNBP1 and three GRM3 single-nucleotide polymorphisms showed nominal significant associations to the disease. However, after correction for multiple testing, there were no statistically significant allele, genotype or haplotype case-control differences.

CONCLUSIONS:

The present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia. Additional studies and meta-analyses are warranted to shed further light on these relationships.

PMID:
19439994
DOI:
10.1159/000218076
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center