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Curr Biol. 2009 May 12;19(9):R381-6. doi: 10.1016/j.cub.2009.03.057.

Signaling pathways regulating zebrafish lateral line development.

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University of Washington, Box 357420, Seattle, WA 98195-7420, USA.


The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.

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