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Clin Endocrinol (Oxf). 2010 Jan;72(1):26-31. doi: 10.1111/j.1365-2265.2009.03614.x. Epub 2009 Apr 25.

Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS).

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1
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE:

To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS).

DESIGN/PATIENTS/MEASUREMENTS:

We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles.

RESULTS:

Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH.

CONCLUSION:

An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.

[Indexed for MEDLINE]

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