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Clin Exp Dermatol. 2009 Jul;34(5):e78-80. doi: 10.1111/j.1365-2230.2009.03221.x. Epub 2009 May 5.

Neonatal haemangiomatosis associated with placental chorioangiomas: report of three cases and review of the literature.

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Department of Paediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.


We report three cases of neonatal haemangiomatosis associated with large placental chorioangioma. Pregnancies were complicated by polyhydramnios, and all mothers underwent amniocentesis to drain the liquid. Steroid treatment was required for two children. Although the theory has been largely disproved in normal haemangiomas, embolization of precursor endothelial cells derived from placental vessels is a likely explanation for the pathogenesis of haemangiomatosis associated with large placental chorioangiomas.

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