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World J Gastroenterol. 2009 May 14;15(18):2290-2.

Fibrosing cholestatic hepatitis following cytotoxic chemotherapy for small-cell lung cancer.

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1
Department of Oncology, Clínica Universidad de Navarra, c/Pío XII 36, 31008 Pamplona (Navarra), Spain.

Abstract

Fibrosing cholestatic hepatitis (FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver, renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy. FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings. Here, we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression. This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor. In addition to a detailed report of the case, a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed.

PMID:
19437574
PMCID:
PMC2682249
[Indexed for MEDLINE]
Free PMC Article
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