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Hippocampus. 2009 Nov;19(11):1051-4. doi: 10.1002/hipo.20633.

Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

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1
Department of Pharmacology, Medical University Innsbruck, Innsbruck, Austria.

Abstract

Dynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to controls. We detected a conspicuously right skewed, bimodal distribution of mRNA levels among patients, suggestive of a dynamic up-regulation of prodynorphin expression in epilepsy. Highest transcript levels were seen postictally. Our data argue for an essential role of dynorphin in the termination of seizures.

PMID:
19437412
PMCID:
PMC3073604
DOI:
10.1002/hipo.20633
[Indexed for MEDLINE]
Free PMC Article
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