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J Biol. 2009;8(3):32. doi: 10.1186/jbiol131. Epub 2009 Apr 16.

The genomic 'inner fish' and a regulatory enigma in the vertebrates.

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1
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. malonej@niddk.nih.gov

Abstract

Information on how genomic information from fish to human encodes the same tissues has until now emerged one gene at a time. The study published in this issue now provides lists of genes and their expression levels for 20 vertebrate tissues spanning 450 million years of vertebrate evolution. It reveals a core set of genes with similar tissue-expression patterns yet no common regulatory signatures--a gene-expression paradox.

PMID:
19435486
PMCID:
PMC2689435
DOI:
10.1186/jbiol131
[Indexed for MEDLINE]
Free PMC Article
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