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Crit Care. 2009;13(2):129. doi: 10.1186/cc7756. Epub 2009 Apr 3.

Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction?

Author information

1
Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.

Abstract

In the recent study by Preissig and Rigby in Critical Care, the authors argue that critical illness hyperglycemia in children with both respiratory failure and cardiovascular failure is due to a primary failure of the beta-cell. However, alternative explanations that the failure is secondary to an increase in insulin resistance leading to beta-cell exhaustion, or a negative impact of exogenous glucocorticoid therapy, may be equally likely.

PMID:
19435475
PMCID:
PMC2689480
DOI:
10.1186/cc7756
[Indexed for MEDLINE]
Free PMC Article

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