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Clin Infect Dis. 2009 Jun 15;48(12):1732-5. doi: 10.1086/599224.

Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection.

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1
Department of Medical Microbiology and Immunology, St. Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands. b.herpers@antonius.net

Abstract

Clostridium difficile infection (CDI) has become more refractory to standard therapy. We describe 4 patients with severe refractory CDI who were successfully treated with tigecycline. Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI.

PMID:
19435431
DOI:
10.1086/599224
[Indexed for MEDLINE]
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