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DNA Cell Biol. 2009 Aug;28(8):397-403. doi: 10.1089/dna.2009.0868.

Bacterial and host interactions of oral streptococci.

Author information

1
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA. jkreth@ouhsc.edu

Abstract

The oral microbial flora comprises one of the most diverse human-associated biofilms. Its development is heavily influenced by oral streptococci, which are considered the main group of early colonizers. Their initial attachment determines the composition of later colonizers in the oral biofilm and impacts the health or disease status of the host. Thus, the role of streptococci in the development of oral diseases is best described in the context of bacterial ecology, which itself is further influenced by interactions with host epithelial cells, the immune system, and salivary components. The tractability of the oral biofilm makes it an excellent model system for studies of complex, biofilm-associated polymicrobial diseases. Using this system, numerous cooperative and antagonistic bacterial interactions have been demonstrated to occur within the community and with the host. In this review, several recent identified interactions are presented.

Comment in

PMID:
19435424
PMCID:
PMC2903342
DOI:
10.1089/dna.2009.0868
[Indexed for MEDLINE]
Free PMC Article

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