Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2009 Mar 15;199(6):801-4.

Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.

Author information

1
Department of Parasitology, Institute for Tropical Medicine, University of Tübingen, Germany.

Abstract

Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.

PMID:
19434912
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center