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Life Sci. 1991;49(24):PL201-6.

Cocaine conditioned place preference is attenuated by chronic buprenorphine treatment.

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Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.


Previous research shows that buprenorphine (BUP), a mixed opioid agonist-antagonist, reduces cocaine use in humans and suppresses cocaine self-administration in monkeys. The present study found that BUP reduces cocaine's ability to condition a place preference in rats. Compared to vehicle treated rats, rats treated with BUP 2 times/day for 2 weeks spent significantly less time in the cocaine conditioned place compared to their respective saline trained controls. No conditioned place preference was shown for BUP alone. These results further implicate a role for the opioid system in cocaine use and stress the importance of differentiating chronic vs. acute opioid effects.

[Indexed for MEDLINE]

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