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Curr Opin Neurol. 2009 Jun;22(3):277-82.

Improving the role of intraventricular antimicrobial agents in the management of meningitis.

Author information

1
Division of Neurosciences Critical Care, Department of Neurology and Anesthesiology-Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. weziai@jhmi.edu

Abstract

PURPOSE OF REVIEW:

The aim is to review the role of intraventricular administration of antimicrobial agents in the treatment of patients with bacterial and fungal meningitis.

RECENT FINDINGS:

This article discusses indications for intraventricular antimicrobial agents, choice of antibiotics, strategies to monitor pharmacokinetics of central nervous system compartments and unanswered issues for this management approach.

SUMMARY:

Intraventricular administration of antimicrobials may be necessary in certain difficult- to- eradicate central nervous system infections. There is a significant need for clinical trials and management guidelines in this area.

PMID:
19434796
DOI:
10.1097/wco.0b013e32832c1396
[Indexed for MEDLINE]

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