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Antimicrob Agents Chemother. 2009 Aug;53(8):3331-6. doi: 10.1128/AAC.00226-09. Epub 2009 May 11.

Pyrazolopyrimidinediones are selective agents for Helicobacter pylori that suppress growth through inhibition of glutamate racemase (MurI).

Author information

1
Infection Discovery, Cancer and Infection Research Area, 35 Gatehouse Drive, Waltham, MA 02451, USA. Boudewijn.deJonge@astrazeneca.com

Abstract

Pyrazolopyrimidinediones are a novel series of compounds that inhibit growth of Helicobacter pylori specifically. Using a variety of methods, advanced analogues were shown to suppress the growth of H. pylori through the inhibition of glutamate racemase, an essential enzyme in peptidoglycan biosynthesis. The high degree of selectivity of the series for H. pylori makes these compounds attractive candidates for novel H. pylori-selective therapy.

PMID:
19433553
PMCID:
PMC2715633
DOI:
10.1128/AAC.00226-09
[Indexed for MEDLINE]
Free PMC Article
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