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Bioorg Med Chem Lett. 2009 Jun 15;19(12):3214-6. doi: 10.1016/j.bmcl.2009.04.108. Epub 2009 May 3.

Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.

Author information

1
Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk1@wyeth.com

Abstract

Cognitive dysfunction is a characteristic of various forms of dementia such as Alzheimer's disease (AD) and a core feature of schizophrenia. As part of our continuing efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT(6) receptor-one of the emerging therapeutic targets in this area. Herein, we report the identification of a novel series of 3-piperidinyl-5-sulfonylindazole derivatives as potent 5-HT(6) antagonists. The synthesis and SAR of this class of compounds are reported.

PMID:
19433358
DOI:
10.1016/j.bmcl.2009.04.108
[Indexed for MEDLINE]

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