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Mol Microbiol. 2009 Jun;72(6):1395-407. doi: 10.1111/j.1365-2958.2009.06731.x. Epub 2009 May 8.

Biogenesis of bacterial membrane vesicles.

Author information

1
Department of Microbiology, University of Washington, 1959 NE Pacific St., Seattle, WA 98195, USA.

Abstract

Membrane vesicle (MV) release remains undefined, despite its conservation among replicating Gram-negative bacteria both in vitro and in vivo. Proteins identified in Salmonella MVs, derived from the envelope, control MV production via specific defined domains that promote outer membrane protein-peptidoglycan (OM-PG) and OM protein-inner membrane protein (OM-PG-IM) interactions within the envelope structure. Modulation of OM-PG and OM-PG-IM interactions along the cell body and at division septa, respectively, maintains membrane integrity while co-ordinating localized release of MVs with distinct size distribution and protein content. These data support a model of MV biogenesis, wherein bacterial growth and division invoke temporary, localized reductions in the density of OM-PG and OM-PG-IM associations within the envelope structure, thus releasing OM as MVs.

PMID:
19432795
PMCID:
PMC2745257
DOI:
10.1111/j.1365-2958.2009.06731.x
[Indexed for MEDLINE]
Free PMC Article

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