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Angew Chem Int Ed Engl. 2009;48(24):4422-5. doi: 10.1002/anie.200900406.

Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis.

Author information

1
Institut für Organische Chemie, Universität des Saarlandes, Postfach 151150, 66041 Saarbrücken, Germany.

Abstract

Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.

PMID:
19431172
DOI:
10.1002/anie.200900406
[Indexed for MEDLINE]

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