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Nat Immunol. 2009 Jun;10(6):587-94. doi: 10.1038/ni.1733.

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.

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The Elie Metchnikoff Department, University of Messina, Messina, Italy.


Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers. Thus, this cell type-specific recognition pathway links lysosomal recognition of bacterial RNA with a robust, host-protective interferon response.

[Indexed for MEDLINE]

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