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Nat Neurosci. 2009 Jun;12(6):725-7. doi: 10.1038/nn.2316. Epub 2009 May 10.

Intracellular zinc inhibits KCC2 transporter activity.

Author information

1
Department of Morphology, Ben Gurion University, Beer-Sheva, Israel. hmichal@bgu.ac.il

Abstract

We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose deprivation attenuated KCC2 activity in a Zn(2+)-dependent manner. The link between Zn(2+) and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission.

PMID:
19430470
PMCID:
PMC2737597
DOI:
10.1038/nn.2316
[Indexed for MEDLINE]
Free PMC Article

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