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Drug Discov Today. 2009 May;14(9-10):465-71. doi: 10.1016/j.drudis.2009.02.007. Epub 2009 Feb 26.

Application of LC/MS to proteomics studies: current status and future prospects.

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  • 1Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. guodong.chen@bms.com

Abstract

Liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology in proteomics studies in drug discovery, including target protein characterization and discovery of biomarkers. This review article will describe current LC/MS approaches in protein characterization, including a bottom-up method for protein identification and quantitative proteomics. We will discuss the investigation of protein post-translational modifications such as glycosylation (glycoproteomics) and phosphorylation (phosphoproteomics) using LC/MS. Future trends in LC/MS with respect to proteomics studies will also be illustrated.

PMID:
19429505
DOI:
10.1016/j.drudis.2009.02.007
[PubMed - indexed for MEDLINE]
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