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Semin Cell Dev Biol. 2009 Feb;20(1):41-8. doi: 10.1016/j.semcdb.2009.01.014. Epub 2009 Feb 3.

Field-effect devices for detecting cellular signals.

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1
Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Campus Jülich, Ginsterweg 1, D-52428 Jülich, Germany.

Abstract

The integration of living cells together with silicon field-effect devices challenges a new generation of biosensors and bioelectronic devices. Cells are representing highly organised complex systems, optimised by millions of years of evolution and offering a broad spectrum of bioanalytical receptor "tools" such as enzymes, nucleic acids proteins, etc. Their combination with semiconductor-based electronic chips allows the construction of functional hybrid systems with unique functional and electronic properties for both fundamental studies and biosensoric applications. This review article summarises recent advances and trends in research and development of cell/transistor hybrids (cell-based field-effect transistors) as well as light-addressable potentiometric sensors.

PMID:
19429490
DOI:
10.1016/j.semcdb.2009.01.014
[Indexed for MEDLINE]
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