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Neurosci Lett. 2009 Mar 27;453(1):58-61. doi: 10.1016/j.neulet.2009.01.067. Epub 2009 Jan 30.

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Author information

1
Department of Neurology, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road, Jinan 250012, PR China.

Abstract

Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures.

PMID:
19429016
DOI:
10.1016/j.neulet.2009.01.067
[Indexed for MEDLINE]

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