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Behav Brain Res. 2009 Aug 12;201(2):239-43. doi: 10.1016/j.bbr.2009.03.004. Epub 2009 Mar 17.

The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex.

Author information

1
Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Blvd, Madison, WI 53719, USA. mrkoenigs@wisc.edu

Abstract

A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results.

PMID:
19428640
PMCID:
PMC2680780
DOI:
10.1016/j.bbr.2009.03.004
[Indexed for MEDLINE]
Free PMC Article

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