Format

Send to

Choose Destination
Gene Expr Patterns. 2009 Sep;9(6):454-60. doi: 10.1016/j.gep.2009.04.004. Epub 2009 May 7.

Dynamic expression of Syndecan-1 during hair follicle morphogenesis.

Author information

1
School of Biological and Biomedical Sciences, Durham University, Durham DH1 3LE, UK. G.D.Richardson@dur.ac.uk

Abstract

Syndecan-1 is a cell-surface heparan-sulphate proteoglycan that is involved in growth factor regulation, cell adhesion, proliferation, differentiation, blood coagulation, lipid metabolism, as well as tumour formation. In this study, investigation of discrete LCM captured dermal cells by semi-quantitative RT-PCR revealed Syndecan-1 mRNA transcripts were expressed only in the dermal condensation (DC) within this skin compartment during murine pelage hair follicle (HF) morphogenesis. Further immunofluorescence studies showed that, during early skin development, Syndecan-1 was expressed in the epidermis while being absent from the mesenchyme. As HF morphogenesis began ( approximately E14.5) Syndecan-1 expression was lost from the epithelial compartment of the HF and activated in HF mesenchymal cells. This Syndecan-1 expression profile was consistent between different hair follicle types including primary and secondary pelage, vibrissa, and tail hair follicles. Furthermore we show by using gene targeted mice lacking Syndecan-1 expression that Syndecan-1 is not required for follicle initiation and development.

PMID:
19427408
DOI:
10.1016/j.gep.2009.04.004

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center