Format

Send to

Choose Destination
Eur J Obstet Gynecol Reprod Biol. 2009 Jul;145(1):85-8. doi: 10.1016/j.ejogrb.2009.04.013. Epub 2009 May 7.

Association between a single nucleotide polymorphism in MTHFR gene and polycystic ovary syndrome.

Author information

1
Washington University, Saint Louis, MO 63130, USA. tjddn1578@hotmail.com

Abstract

OBJECTIVE:

The aim of the present study was to investigate whether there is an association between the C677T polymorphism in MTHFR and PCOS in a Korean population.

STUDY DESIGN:

The prevalence of MTHFR gene was compared between women with PCOS (n=227) and normal patients (n=115) using restriction fragment length polymorphism (RFLP) analysis. The HapAnalyzer was used to analyze the genotype of MTHFR polymorphism in PCOS and control subjects. We considered a p-value less than 0.05 as statistically significant.

RESULTS:

The frequency of C/C, C/T, and T/T genotype showed similar proportion between PCOS and control subjects. In addition, the frequencies of co-dominant (p-value=0.8334, odds ratio (OR)=1.04), dominant (p-value=0.8749, OR=0.96) and recessive alleles (p-value=0.5574, OR=1.22) did not show any association between PCOS and control subjects.

CONCLUSION:

Our data demonstrate that the C677T polymorphism of MTHFR gene is not associated with PCOS in a Korean population, suggesting that the C677T polymorphism in MTHFR may have different influences in various ethnic groups and diseases.

PMID:
19427093
DOI:
10.1016/j.ejogrb.2009.04.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center