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Alcohol Clin Exp Res. 2009 Aug;33(8):1476-86. doi: 10.1111/j.1530-0277.2009.00978.x. Epub 2009 May 4.

Mood-related drinking motives mediate the familial association between major depression and alcohol dependence.

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1
Department of Psychology, University of Southern California, Los Angeles, California 90089-1061, USA.

Abstract

BACKGROUND:

Major depression and alcohol dependence co-occur within individuals and families to a higher than expected degree. This study investigated whether mood-related drinking motives mediate the association between major depression and alcohol dependence, and what the genetic and environmental bases are for this relationship.

METHODS:

The sample included 5,181 individuals from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, aged 30 and older. Participants completed a clinical interview which assessed lifetime major depression, alcohol dependence, and mood-related drinking motives.

RESULTS:

Mood-related drinking motives significantly explained the depression-alcohol dependence relationship at both the phenotypic and familial levels. Results from twin analyses indicated that for both males and females, the familial factors underlying mood-related drinking motives accounted for virtually all of the familial variance that overlaps between depression and alcohol dependence.

CONCLUSIONS:

The results are consistent with an indirect role for mood-related drinking motives in the etiology of depression and alcohol dependence, and suggest that mood-related drinking motives may be a useful index of vulnerability for these conditions.

PMID:
19426164
PMCID:
PMC2844888
DOI:
10.1111/j.1530-0277.2009.00978.x
[Indexed for MEDLINE]
Free PMC Article
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