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Mod Rheumatol. 2009;19(3):338-47. doi: 10.1007/s10165-009-0168-y. Epub 2009 May 8.

Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.

Author information

1
Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA. yokogawan@aol.com

Abstract

We report two cases of hydralazine-induced vasculitis with rare complications: pulmonary renal syndrome and digital gangrene. We also review 68 published cases of hydralazine-induced vasculitis. Hydralazine-induced vasculitis mimics idiopathic antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis. However, it also produces other autoantibodies, such as antinuclear antibodies, antihistone antibodies, anti-dsDNA antibodies, and antiphospholipid antibodies. Patients with hydralazine-induced vasculitis typically have a more severe course than those with hydralazine-induced lupus, predominantly due to renal vasculitis, and require a more aggressive treatment.

PMID:
19424772
DOI:
10.1007/s10165-009-0168-y
[Indexed for MEDLINE]

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