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J Microbiol Immunol Infect. 2009 Feb;42(1):54-62.

Detection and characterization of class 1 integrons among carbapenem-resistant isolates of Acinetobacter spp. in Malaysia.

Author information

1
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Abstract

BACKGROUND AND PURPOSE:

To detect and characterize class 1 integrons among carbapenem-resistant strains of Acinetobacter spp. at University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.

METHODS:

Thirty nine carbapenem-resistant Acinetobacter strains were obtained from UMMC from August 2003 to March 2004 and analyzed for the presence of bla(IMP) genes and class 1 integrons.

RESULTS:

Class 1 integrons were detected in 31 of 39 strains. Two Acinetobacter calcoaceticus strains harbored an integron-borne bla(IMP-4) metallo-beta-lactamase, 1 of which was located on a 36-kb plasmid. Two different amplified products were found in the 31 isolates with 3 restriction pattern profiles 1, 2, and 3. Correlation was observed between carriage of class 1 integrons and genomic relatedness among these isolates, indicating that particular mechanisms of carbapenem resistance could have been acquired by genotypically distinct clinical isolates of Acinetobacter spp.

CONCLUSION:

Although class 1 integrons are widely disseminated among clinical isolates of Acinetobacter spp. they do not play a major role in the spread of carbapenem resistance.

PMID:
19424559
[Indexed for MEDLINE]

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