Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2009 Jun;10(6):373-84. doi: 10.1038/nrm2693. Epub 2009 May 8.

Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.

Author information

1
University of Texas M. D. Anderson Cancer Center, Science Park Research Division, Department of Carcinogenesis, Smithville, Texas 78957, USA. ashbym@stanford.edu

Abstract

Chromatin-modifying factors have essential roles in DNA processing pathways that dictate cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 chromatin-remodelling complexes, to regulate transcriptional processes is well established. However, recent studies reveal that the INO80 and SWR1 complexes have crucial functions in many other essential processes, including DNA repair, checkpoint regulation, DNA replication, telomere maintenance and chromosome segregation. During these diverse nuclear processes, the INO80 and SWR1 complexes function cooperatively with their histone substrates, gamma-H2AX and H2AZ. This research reveals that INO80 and SWR1 ATP-dependent chromatin remodelling is an integral component of pathways that maintain genomic integrity.

PMID:
19424290
DOI:
10.1038/nrm2693
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center