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J Chemother. 2009 Apr;21(2):165-9.

Efficacy and tolerability of linezolid in chronic osteomyelitis and prosthetic joint infections: a case-control study.

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1
4th Department of Internal Medicine, University of Athens, Greece.

Abstract

Clinical experience of prolonged use of linezolid in patients with bone infections is accumulating. However more efficacy and safety data are required. this is a case-control study of patients who received linezolid for difficult-to-treat, intolerant or resistant-to-other-antibiotics bone infections. Linezolid was administered i.v. or orally in 34 patients. Results concerning efficacy and safety were compared to a group of well-matched controls. The clinical arrest rate was 74% in the linezolid group and 68% in the control group (p=NS). treatment was discontinued in 14 (44%) patients of the linezolid group and in 2 (6%) patients of the control group due to adverse events. In the linezolid group 11 (33%) patients developed anemia and 3 (9%) developed thrombocytopenia that led to discontinuation of treatment. Linezolid is effective in a substantial proportion of patients, but the incidence of hematologic adverse events makes close follow-up and laboratory monitoring mandatory.

PMID:
19423469
DOI:
10.1179/joc.2009.21.2.165
[Indexed for MEDLINE]

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